Anti-inflammatory effect of omega-7 against doxorubicin-induced cardiotoxicity in male rats: An observational study

Background: Doxorubicin is a crucial anticancer medication, however, cardiotoxicity severe adverse effect of doxorubicin therapy. Various mechanisms, including inflammation, have been postulated to account for this negative effect. The omega-7 fatty acid polyunsaturated with anti-inflammatory and antioxidant properties. Therefore, the study's objective was see whether had any possible protective benefits against doxorubicin-induced in male rats. Methods: 28 Wister rats were split into four groups (seven per group). Group 1 (negative control): healthy animals received normal saline orally as vehicle eight successive days sacrificed on day nine. Group 2 (positive that single dose hydrochloride (IP 15mg/kg) next day. 3: the administered omega-7 at 100 mg/kg/day days. A injection IP (15 mg/kg) given 10. 4: animal 300 10. Serum collected used measure lactate dehydrogenase, creatinine kinase-MB, tumor necrosis factor-alpha, interleukin-6, interleukin-1beta. Results: Lactate dehydrogenase kinase-MB levels group 3 (100mg/kg) significantly lower than (p>0.05) 4 (300mg/kg) 2. Tumor interleukin-1beta considerably omega-7-treated (100 300mg/kg) positive control (p<0.05). Conclusion: Through mechanism involving reduction may preserve cardiac tissue damage.